Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09727-zInhibition of the histone methyltransferase NSD2 and the androgen receptor in preclinical models can reverse lineage plasticity to suppress tumour growth and promote cell death in multiple subtypes of castration-resistant prostate cancer.

Nature, Published online: 26 November 2025; doi:10.1038/d41586-025-03853-4The nations next generation of scientists and technologists will shape the coming decades.

Trailing at the half, No. 16 Texas, backed by a standout effort from quarterback Arch Manning, rallied to defeat rival Texas A&M 27-17, spoiling the No. 3 Aggies' undefeated season and SEC title-game hopes at Darrell K Royal-Texas Memorial Stadium.

No. 5 LSU set an NCAA record with its seventh consecutive 100-point game Friday night, routing Marist 113-53 at the Paradise Jam tournament.

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The South African government is investigating how more than a dozen men unwittingly ended up on the front line in Russias war on Ukraine.

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Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09793-3Ultralow-power ferroelectric field-effect transistors are used to achieve low-power NAND flash memory, overcoming the trade-off between multi-level capability and power efficiency and paving the way for next-generation storage memory.

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09797-zA meta-analysis of 168 studies reveals that economic inequality is not significantly associated with subjective well-being or mental health.

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09805-2The brain can flexibly perform multiple tasks by compositionally combining task-relevant neural representations.

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09752-yA glasses-free three-dimensional display, which is as large as a conventional desktop screen and has a viewing angle larger than 100, is achieved by an artificial intelligence-powered optimization algorithm, which adapts the virtual images sent around each eye in real time.

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09673-wA mechano-intelligent transmission mechanism based on the slipknot delivers precise force signals for clinical practice and robotic operations such as minimally invasive surgery and tendon-driven robotics.

Utah Mammoth captain Clayton Keller played in Friday night's 4-3 loss to the Dallas Stars, one day after the unexpected death of his father, and as a tribute, the 27-year-old forward was named the game's first star at the American Airlines Center.

Despite Fernando Mendoza's struggles, No. 2 Indiana rolled to a 56-3 win over rival Purdue, completing the first perfect regular season in school history and clinching a spot in the Big Ten title game.

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The Trump administration has been trying to repair the damage from the detention of hundreds of South Koreans in an immigration raid in Georgia.

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09779-1Thousands of centromeres were identified and tracked across two major fungal clades, showing that new centromeres spread progressively and that the kinetochore acts as a filter to determine which new centromere variants are tolerated.

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09796-0A mode of brain organization that connects visual and bodily reference frames may translate raw sensory impressions into more abstract formats that are useful for action, social cognition and semantic processing.

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09743-zData provided by Amazonian peoples are used to estimate the value of wild animals as a source of food, including its spatial distribution and nutritional value, providing information that will be key for improved management of forest ecosystems in the region.

Nature, Published online: 26 November 2025; doi:10.1038/d41586-025-03649-6The DNA of ancient individuals dating to between 10,000 and 150 years ago reveals the existence of a long-standing, yet previously uncharacterized, lineage in the Southern Cone of South America a region comprising what is now Argentina, Chile and Uruguay. People with this ancestry produced offspring with other, pre-existing groups in surrounding regions. Genomic data from present-day inhabitants attest to the genetic continuity of the lineage in central Argentina.

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09786-2Complex prophage integration dynamics, including low-level induction, cross-family host range and transposase-mediated mobilization, challenge existing paradigms and deepen our understanding of phagebacterial interactions in the human gut microbiome.

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2025-11-29T06:43:05Z ISTANBUL (AP) Two oil tankers said to be part of Russias shadow fleet that were set ablaze off Turkeys Black Sea coast may have been hit by mines, drones or missiles, a senior Turkish official said Saturday.Tankers Kairos and Virat were struck in quick succession late Friday afternoon, prompting rescue operations. Crew members on board both vessels were reported to be safe.Turkish Transport and Infrastructure Minister Abdulkadir Uraloglu said rescue services first received reports that the Kairos may have hit a mine before being told of an explosion on the Virat.Our crews indicate that there were explosions on the other ship and that these were also caused by external interference, Uraloglu told broadcaster NTV early Saturday.The first things that come to mind for external interference could be a mine, a missile, a marine vessel or a drone. We dont have definitive information on this, he added. The OpenSanctions database, which tracks people or organizations involved in sanctions evasion, describes the vessels as part of a shadow fleet of ships used to evade sanctions imposed on Russia following its 2022 invasion of Ukraine. Ukraine has carried out successful naval strikes against Russian shipping during the war, particularly using explosives-packed marine drones. However, Ukrainian missions have largely been limited to the waters of the northern Black Sea. The Gambian-flagged Kairos caught fire in the Black Sea approximately 28 nautical miles (52 kilometers) off the coast of Turkeys Kocaeli province, Turkeys Directorate General of Maritime Affairs said. It was sailing empty toward Russias Novorossiysk port.Within an hour, the maritime authority reported that a second tanker, Virat, was struck while sailing in the Black Sea about 35 nautical miles (64 kilometers) off the Turkish coast. It did not provide further details. Rescue teams were dispatched to the scene to provide assistance. All 20 crew members aboard the Virat were safe, although heavy smoke was reported in the engine room, the maritime authority said.All 25 crew aboard the Kairos were safely evacuated, Kocaeli Gov. Ilhami Aktas said.The VesselFinder website showed the Virat was anchored north of the Bosphorus, not far from its current position, on Nov. 4. The Kairos last position was on Nov. 26 south of the Dardanelles Strait connecting the Aegean Sea and the Sea of Marmara.The United States sanctioned the Virat in January this year, followed by the European Union, Switzerland, the United Kingdom and Canada, according to the OpenSanctions website. Similarly, the EU sanctioned the Kairos in July this year, followed by the U.K. and Switzerland.The shadow tanker fleet continues to provide multibillion-dollar revenues for the Kremlin bypassing sanctions, disguising its activities under the flags of third countries, using complex schemes to conceal owners and poses significant environmental threats, OpenSanctions says in its website entry on the Kairos.The Virat, built in 2018, uses irregular and high-risk shipping practices and has previously sailed under the flags of Barbados, Comoros, Liberia and Panama, OpenSanctions says. The Kairos, formerly flagged as Panamanian, Greek and Liberian, was built in 2002.Ukraines military intelligence service, the GUR, says on its website that both ships visit Russian ports and have a history of shutting off their automatic identification systems, which transmit a ships position.They have also docked at ports in China, Turkey and India, among other locations.-Fraser reported from Ankara, Turkey RSShttps://feedx.net https://feedx.site

Pope Leo XIV, center, visits the Sultan Ahmed Mosque in Istanbul, Saturday, Nov. 29, 2025. (AP Photo/Domenico Stinellis)2025-11-29T06:57:11Z ISTANBUL, Turkey (AP) Pope Leo XIV visited Istanbuls Blue Mosque on Saturday at the start of an intense day of meetings and liturgies with Turkeys religious leaders and a Mass for the countrys tiny Catholic community.The head of Turkeys Diyanet religious affairs directorate showed Leo the soaring tiled dome of the mosque and the Arabic inscriptions on its columns, as Leo nodded in understanding. The Vatican had said Leo would observe a brief minute of silent prayer there, but it wasnt clear if he had. The imam of the mosque, Asgin Tunca, said he had invited Leo to pray but the pope declined.Speaking to reporters after the visit, Tunca said he had told the pope that the mosque was Allahs house.Its not my house, not your house, (its the) house of Allah, he said. He said he told Leo: If you want, you can worship here, I said. But he said, Thats OK. He wanted to see the mosque, wanted to feel (the) atmosphere of the mosque, I think. And was very pleased, he said.Leo was following in the footsteps of his recent predecessors, who all made high-profile visits to the Sultan Ahmed Mosque, as it is officially known, in a gesture of respect to Turkeys Muslim majority. Leo removed his shoes and walked through the carpeted mosque in his white socks. Past popes have also visited the nearby Hagia Sophia landmark, once one of the most important historic cathedrals in Christianity and a United Nations-designated world heritage site. But Leo left that visit off his itinerary on his first trip as pope. In July 2020, Turkey converted Hagia Sophia from a museum back into a mosque, a move that drew widespread international criticism, including from the Vatican.After the mosque visit, Leo held a private meeting with Turkeys Christian leaders at the Syriac Orthodox Church of Mor Ephrem. In the afternoon, he was expected to pray with the spiritual leader of the worlds Orthodox Christians, Patriarch Bartholomew, at the patriarchal church of Saint George. He will end the day with a Catholic Mass in Istanbuls Volkswagen Arena for the countrys Catholic community, who number 33,000 in a country of more than 85 million people, most of whom are Sunni Muslim.Leo had prayed with these Christian leaders on Friday in Iznik, at the site of the A.D. 325 Council of Nicaea, the highlight of his trip. The occasion was to mark the 1,700th anniversary of the council, the unprecedented meeting of bishops that produced the creed, or statement of faith, that is still recited by millions of Christians today.Standing over the ruins of the site, the men recited the creed. Leo urged them to overcome the scandal of the divisions that unfortunately still exist and to nurture the desire for unity.Such unity, he said, was of particular importance at a time marked by many tragic signs, in which people are subjected to countless threats to their very dignity.The Nicaea gathering took place at a time when the Eastern and Western churches were still united. They split in the Great Schism of 1054, a divide precipitated largely by disagreements over the primacy of the pope, and then in other splintering divisions. But even today, Catholic, Orthodox and most historic Protestant groups accept the Nicaean Creed, making it a point of agreement and the most widely accepted creed in Christendom. As a result, celebrating its origins at the site of its creation with the spiritual leaders of the Catholic and Orthodox churches and other Christian representatives marked a historic moment in the centuries-old quest to reunite all Christians. ___Associated Press religion coverage receives support through the APs collaboration with The Conversation US, with funding from Lilly Endowment Inc. The AP is solely responsible for this content. NICOLE WINFIELD Winfield has been on the Vatican beat since 2001, covering the papacies of St. John Paul II, Pope Benedict XVI and the Francis pontificate and traveling the world with them.

Passengers wait in line at All Nippon Airways' counter at Haneda airport in Tokyo Saturday, Nov. 29, 2025. A sign, right, reads " Flight cancellation counter." (Takahiko Kanbara/Kyodo News via AP)2025-11-28T22:43:09Z Airlines around the world canceled and delayed flights heading into the weekend to fix software on a widely used commercial aircraft after an analysis found the computer code may have contributed to a sudden drop in the altitude of a JetBlue plane last month.Airbus said Friday that an examination of the JetBlue incident revealed that intense solar radiation may corrupt data critical to the functioning of flight controls on the A320 family of aircraft. The FAA joined the European Union Aviation Safety Agency in requiring airlines to address the issue with a new software update. More than 500 U.S.-registered aircraft will be impacted. The EU safety agency said it may cause short-term disruption to flight schedules. The problem was introduced by a software update to the planes onboard computers, according to the agency.In Japan, All Nippon Airways, which operates more than 30 planes, canceled 65 domestic flights for Saturday. Additional cancellations on Sunday were possible, it said. The software change comes as U.S. passengers were beginning to head home from the Thanksgiving holiday, which is the busiest travel time in the country. American Airlines has about 480 planes from the A320 family, of which 209 are affected. The fix should take about two hours for many aircraft and updates should be completed for the overwhelming majority on Friday, the airline said. A handful will be finished Saturday. Stay up to date with the news and the best of AP by following our WhatsApp channel. Follow on American expected some delays but it said it was focused on limiting cancellations. It said safety would be its overriding priority. Air India said via the social platform X that its engineers were working on the fix and completed the reset on more 40% of aircraft that need it. There were no cancellations, it said.Delta said it expected the issue to affect less than 50 of its A321neo aircraft. United said six planes in its fleet are affected and it expects minor disruptions to a few flights. Hawaiian Airlines said it was unaffected. Mike Stengel, a partner with the aerospace industry management consulting firm AeroDynamic Advisory, said the fix could be addressed between flights or on overnight plane checks. Definitely not ideal for this to be happening on a very ubiquitous aircraft on a busy holiday weekend, Stengel said from Ann Arbor, Michigan. Although again the silver lining being that it only should take a few hours to update the software.At least 15 JetBlue passengers were injured and taken to the hospital after the Oct. 30 incident on board the flight from Cancun, Mexico, to Newark, New Jersey. The plane was diverted to Tampa, Florida.Airbus, which is registered in the Netherlands but has its main headquarters in France, is one of the worlds biggest airplane manufacturers, alongside Boeing. The A320 is the primary competitor to Boeings 737, Stengel said. Airbus updated its engine in the mid-2010s, and planes in this category are called A320neo, he said. The A320 is the worlds bestselling single-aisle aircraft family, according to Airbus website.___Associated Press writers Mari Yamaguchi in Tokyo and Jennifer Kelleher in Honolulu contributed. AUDREY McAVOY McAvoy is a Honolulu-based reporter who covers news in Hawaii and beyond. twitter mailto

Nature, Published online: 26 November 2025; doi:10.1038/d41586-025-03451-4Fossils newly discovered in Ethiopia indicate that previously unidentified foot bones belong to the ancient human relative Australopithecus deyiremeda.

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09760-yControlling pairs of nitrogen vacancy centres enables the measurement of magnetic correlations below the optical diffraction limit, and the use of entangled pairs shows a linear scaling of the measurement sensitivity with readout noise, as opposed to the quadratic scaling that would be obtained with unentangled spins.

Nature, Published online: 26 November 2025; doi:10.1038/d41586-025-03786-yHistory repeating.

Nature, Published online: 26 November 2025; doi:10.1038/d41586-025-03816-9Cells have evolved elaborate mechanisms to eliminate unwanted proteins and maintain homeostasis. Inhibitors of a diverse family of enzymes called kinases can co-opt and supercharge these protein-degradation mechanisms to prompt kinase degradation.

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09765-7Soil compaction traps ethylene around roots, which causes transcriptional upregulation of Auxin Response Factor1, resulting in decreased root cortical cell wall thickness and thereby promoting root radial expansion.

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Archaeologist from Sudan's National Museum Dr Shadia Abdrabo, poses at her office at the French National Institute for Art History (INHA) in Paris, Wednesday, Oct. 29, 2025. (AP Photo/Michel Euler)2025-11-29T07:17:34Z PARIS (AP) In a dimly lit office in a corner of the French National Institute for Art History, Sudanese archaeologist Shadia Abdrabo studies a photograph of pottery made in her country around 7,000 B.C. She carefully types a description of the Neolithic artifact into a spreadsheet.As the war between the Rapid Support Forces (RSF) and the Sudanese Armed Forces (SAF) rages on, the curator from Sudans National Corporation for Antiquities and Museums (NCAM) is on a yearlong research grant in France with one mission: to build an online database of the African nations archaeological sites, museum collections and historical archives.Soon after the war in Sudan started, in April 2023, museums were looted and destroyed. Its unclear what exactly went missing, but Abdrabo says her task is to find out and time is of the essence.We have to work fast to secure our collections. Weve already lost two museums and we dont want to lose more, Abdrabo told The Associated Press. She says two regional museums in El Geneina and Nyala were almost completely destroyed, while in Khartoum, the National Museum which held an estimated 100,000 objects before the war was ransacked by militias who posted videos online of their fighters inside the storeroom. The National Museum had pieces dating back to prehistoric times, including from the Kerma Kingdom and the Napatan era when Kushite kings ruled the region as well as from the Meroitic civilization that built Sudans pyramids. Other galleries displayed later Christian and Islamic objects.Among its most valuable items were mummies dating back to 2,500 B.C., some of the oldest and most archaeologically significant in the world as well as royal Kushite treasures. Entire archives vanishedUNESCO raised the alarm on reports of plundering saying the threat to culture appears to have reached an unprecedented level.My heart was broken, you know? Its not just objects that we lost. We lost research, we lost studies, we lost many things, Abdrabo said.Last month, hundreds of people were left dead and more than 80,000 others forced into displacement after the capture of North Darfurs capital, El Fasher, by the RSF. For Abdrabo the work is deeply personal.Im from Nubia, from the north, an area filled with monuments, archaeological sites and ancient life, she said. The region was home to some of the worlds earliest kingdoms that rivaled ancient Egypt in power and wealth.She was working at the national museum in the capital Khartoum when the war started.We thought it would finish soon but then life started getting really difficult: not just the bombing, but there was no electricity, no water, she said. With her three sisters, she fled north first to Atbara, then to Abri, and eventually to Port Sudan.During that time, Abdrabo and her NCAM colleagues worked tirelessly to try and protect Sudans 11 museums and sites some designated with UNESCO World Heritage status moving pieces to safe rooms and secret locations.But efforts to protect Sudans art were too slow, said Ali Nour, a Sudanese cultural heritage advocate.While applications were being drafted, sites were being emptied. While risk assessments were reviewed, entire archives vanished, Nour wrote in an article for the U.K.-based International Institute for Conservation of Historic and Artistic Works. Urgent recovery effortsUNESCO said it carried out inventories, trained police and customs officers to recognize stolen antiquities, while appealing to collectors to refrain from acquiring or taking part in the import, export or transfer of ownership of cultural property from Sudan.But, unlike similar cultural emergencies that followed wars in Afghanistan and Iraq, Sudan has not benefited from strong media coverage denouncing the degradation and plundering of its cultural heritage,' according to researcher Meryam Amarir. This lack of visibility has reduced the international response.Ancient Sudan was connected, through trade and military activity, with Egypt, the Mediterranean world and Mesopotamia, and was the source of much of the gold available in the region, according to Geoff Emberling of the Kelsey Museum of Archaeology at the University of Michigan. If were interested in these ancient cultures, then we have to be interested in Sudan, said Emberling, who is involved with the recently established Sudan Cultural Emergency Recovery Fund.The task force, requested by NCAM, aims to unite institutions, scholars, and donors around the urgent recovery efforts of Sudans heritage.What Shadia Abdrabo is doing is urgently essential establishing whats missing, Emberling told the AP. And with a team of about 15 Sudanese now working in the museum in Khartoum to clean and restore what has been damaged, they will soon be able to compare what remains there now. I cry when I talk about thisAbdrabo has funding until April 2026 to finish compiling the data and building a platform, but she worries it wont be enough time.The work is painstaking. Some datasets arrive as spreadsheets, others as handwritten inventories or photographs taken decades ago. Colleagues at the Louvre, the British Museum and others lend support but she works mostly alone.Im trying to finish this database but its a lot. Ive done about 20% of the work. Just for the national museums, Ive recorded 1,080 objects so far and then I have to do other museums, sites, archives I need to add pictures, ID numbers, coordinates As the winter settles over Paris, the crisis in Sudan drives Abdrabo.We are working on tracking what has been looted, she said. I cry when I talk about this. My only goal and message is to bring back as much as possible, to do as much as I can for Sudan, but its not easy for us.Its not just the war itself, but the consequences of it that could affect the countrys heritage: militias, people displaced its not safe for the art to be in unsecure locations, she added.Until the war finishes we just dont know what is going to happen.

Nature, Published online: 26 November 2025; doi:10.1038/d41586-025-03885-wEngineered T cells that have been used to treat ulcerative colitis, rheumatoid arthritis and lupus show promising results.

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09803-4Liver-restricted viral infection in mice results in secondary lymphoid organ dormancy and the compensatory induction of specialized lymphoid tissue in the liver, the structural features and functional outputs of which are closely mirrored in humans.