Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09866-3Approaches combining genetic association and Perturb-seq data that link genetic variants to functional programs to traits are described.

Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03577-5The genetic engineering of mosquitoes offers a potentially transformative, self-sustaining opportunity for malaria control and elimination in Africa. By rendering mosquitoes unable to transmit the malaria parasite, even when they bite humans, the technology provides a mosquito-based intervention to complement existing efforts.

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09685-6Engineering of local Anopheles gambiae under containment enables the generation of a transgenic strain equipped with non-autonomous gene drive capabilities that robustly inhibits genetically diverse Plasmodium falciparum isolates obtained from naturally infected children.

Mavericks center Dereck Lively II will undergo season-ending surgery on his right foot to address lingering discomfort, the team announced Wednesday.

Are Tyran Stokes, Marcus Spears Jr. and A.J. Williams secure at the top of their respective classes?

Liverpool goalkeeper Alisson is a target for AC Milan. Transfer Talk has the latest news and rumors.

Lea Micheles star turn in Chess. Kara Young as an 8-year-old. A 12-minute monologue delivered from a cloud. These are our favorite scenes from this year.

President Trumps unusual decision to involve himself in the governments review of the deal puts his antitrust chief in an awkward position.

The school has been brought to heel by conservative critics of higher education. It is part of a broader transformation at the states universities.

In the 1970s, she photographed Andy Warhol and Debbie Harry on wild nights at Studio 54. Now shes chronicling a new generation.

In the Ozarks, the growing college town of Fayetteville, Ark., is using clean energy to power city facilities and embracing nature-based solutions to climate threats.

Elon Musk attends the Saudi Investment Forum at the Kennedy Center, Wednesday, Nov. 19, 2025, in Washington. (AP Photo/Evan Vucci)2025-12-10T17:14:01Z Mega billionaire Elon Musk, in a friendly interview with his aide and conservative influencer Katie Miller, said his efforts leading the Department of Government Efficiency were only somewhat successful and he would not do it over again. The Tesla and SpaceX CEO, who also owns the social media platform X, still broadly defended President Donald Trumps controversial pop-up agency that Musk left in the spring before it shuttered officially last month. Yet Musk bemoaned how difficult it is to remake the federal government quickly, and he acknowledged how much his businesses suffered because of his DOGE work and its lack of popularity.We were a little bit successful. We were somewhat successful, he told Miller, who once worked as a DOGE spokeswoman charged with selling the agencys work to the public.When Miller pressed Musk on whether he would do it all over again, he said: I dont think so. ... Instead of doing DOGE, I would have, basically, built ... worked on my companies. Almost wistfully, Musk added, They wouldnt have been burning the cars a reference to consumer protests against Tesla. Still, things certainly have turned up for Musk since his departure from Trumps administration. Tesla shareholders approved a pay package that could make Musk the worlds first trillionaire.Musk was speaking as a guest on the Katie Miller Podcast, which Miller, who is married to top Trump adviser Stephen Miller, launched after leaving government employment to work for Musk in the private sector. The two sat in chairs facing each other for a conversation that lasted more than 50 minutes and spanned topics from DOGE to Musks thoughts on AI, social media, conspiracy theories and fashion. Miller did not press Musk on the innerworkings of DOGE and the controversial manner in which it took over federal agencies and data systems. Musk credited the agency with saving as much as $200 billion annually in zombie payments that he said can be avoided with better automated systems and coding for federal payouts. But that number is dwarfed by Musks ambitious promises at one time that an efficiency commission could measure savings in the trillions. BILL BARROW Barrow covers U.S. politics for The Associated Press. He is based in Atlanta. twitter mailto

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09821-2A forward genetic screen in Caenorhabditis elegans reveals that decreased levels of the ferredoxin FDX2 suppress the loss of frataxin in worms and in mice by relief of FDX2 inhibition of frataxin-stimulated NFS1 activity.

Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03732-yThe emission of photons by excited nuclei has been explored for timekeeping and sensing, but nuclear processes that eject electrons offer practical advantages.

Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03827-6More than 7,000 languages are spoken around the world, but the human brain becomes highly specialized to process speech in an individuals own language. Recordings from human brains reveal the shared and language-specific neural mechanisms that arise in the superior temporal gyrus to achieve this feat.

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09753-xA Review of the impacts of short-lived halogens on air quality and climate identifies gaps in our knowledge of short-lived halogen emissions, chemistry, and the environmental and climate impacts.

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09800-7Experimental observations in small-grained polycrystals suggest a new concept of considering metallic grain boundaries not as defects but as separate defect-containing lattices, providing a potential explanation for the deformation behaviour of nanocrystalline metals.

First baseman Pete Alonso and the Baltimore Orioles are finalizing a five-year, $155 million contract, sources told ESPN's Jeff Passan.

ESPN's Stuart Scott changed the way we talked about sports, and in doing so put himself on ESPN's Mount Rushmore, writes Michael Wilbon.

Commanders QB Jayden Daniels aggravated his elbow injury on a hit against the Vikings and will not play in Week 15 against the Giants.

Travis Kelce said on the "New Heights" podcast that he is struggling to find the answers for his play this season.

Less than a year after his first league start, Josh King is earning praise from sporting directors and agents alike.

The United States history in the region includes several about-faces, contradictions and missteps.

Through their reporting, the columnists share how regular citizens stand up to governments they oppose.

Sophie Kinsella, the author of Confessions of a Shopaholic, packs love, laughter and a harrowing real-life health ordeal into a 133-page novella.

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Chad Walker, right, and Adrienne Higbee help an out-of-town neighbor with their property as the Skykomish River rises on Wednesday, Dec. 10, 2025, in Index, Snohomish County, Wash. (Nick Wagner /The Seattle Times via AP)2025-12-10T05:18:44Z PORTLAND, Ore. (AP) Pacific Northwest residents braced for another round of heavy rain, flooding and evacuations on Wednesday after a powerful storm clobbered the region a day earlier, swelling rivers, closing roads and prompting high water rescues.Rivers across western Washington were rising again after a brief morning lull, the National Weather Service said, warning travelers to use caution. Major or record flooding was expected along the Skagit and Snohomish rivers north of Seattle, and overtopping of levees was possible, the National Water Center said.Evacuations were ordered Wednesday in part of the town of Orting in the foothills of Mt. Rainier south of Seattle. Officials said there was a significant threat to life or property amid extremely high river levels and concerns about levees upstream on the Puyallup River. Teams planned to go door to door to alert residents, and an evacuation center was set to open. Forecasters warn that the worst river flooding is still to come. By early Wednesday, parts of the Cascade Range in Washington were reporting impressive hourly rain rates near or above a half-inch (1.2 centimeters) per hour, the weather service posted on X. The Paradise area on the slopes of Mount Rainier picked up 3.25 inches (8.2 centimeters) of rain in 10 hours. On Tuesday, a storm caused power outages, flooding and school closures in parts of Oregon and Washington. Drivers navigated debris slides and water that closed roads and submerged vehicles. Stay up to date with the news and the best of AP by following our WhatsApp channel. Follow on Fire officials northeast of Seattle said rescue crews used inflatable kayaks to pull people from stranded cars, and carried another person about a mile (1.6 kilometers) to safety after rising water trapped them in the woods. Washington Gov. Bob Ferguson said Tuesday night that the states Emergency Operations Center had moved to its highest activation level because of the rain and wind. Major rivers are forecast to crest later this weekThe Skagit River near the northern Washington town of Concrete was forecast to rise more than 15 feet (4.6 meters) above major flooding levels by Thursday, which would break a record, according to the National Water Prediction Service.Harrison Rademacher, a meteorologist with the weather service in Seattle, described the atmospheric river soaking the region as a jet stream of moisture stretching across the Pacific Ocean with the nozzle pushing right along the coast of Oregon and Washington.The weather service expects several days of heavy rainfall along the coast and more than a foot (30 centimeters) of new snow in the northern Rockies in northwestern Wyoming. Flood watches were in effect, with scattered flash flooding possible along the coast and into the Cascade Range through midweek.Along Interstate 5 between Seattle and Portland, firefighters conducted five rescues for people who tried to drive on flooded roads, including a semitruck driver, said Malachi Simper, spokesperson for Lewis County Fire Protection District 5. Authorities also rescued a family of six from their home in Chehalis, he said, adding that the road to the house was under about 4 feet (1.2 meters) of water at the time. No one was injured. Authorities go door to door warning about floodingDeputies in Washington knocked on doors in certain neighborhoods to warn residents of imminent flooding, and evacuated a mobile home park along the Snohomish River. The city of Snohomish issued an emergency proclamation, while workers in Auburn, south of Seattle, installed temporary flood control barriers along the White River.Farther south near the Oregon border, the city of Longview on the Columbia River said it was opening a severe weather shelter Tuesday night.Another storm system is expected to bring more rain starting Sunday, Rademacher said. The pattern looks pretty unsettled going up to the holidays.In southeast Alaska, an arctic blast could bring wind chills as low as minus 50 degrees (minus 45.6 Celsius) in Skagway and minus 15 degrees (minus 26 Celsius) in the capital Juneau, according to the weather service. Severe weather also targets the Upper MidwestA fast-moving storm brought freezing rain, high winds and heavy snow to the Upper Midwest on Tuesday, forcing some schools to close or move to virtual lessons.Parts of central and northern Minnesota and northwest Wisconsin saw heavy snow, while the Twin Cities metro and southwest Minnesota got a mix of wintry weather. St. Cloud, Minnesota, got nearly 6 inches (15 centimeters) of snow by Wednesday morning, the weather service said. The storm was heading into the Great Lakes region on Wednesday. Parts of upstate New York near Lake Ontario, including the western Adirondacks, were under a winter storm warning with heavy snow expected. ___ CLAIRE RUSH Rush is an Associated Press reporter covering Oregon state government and general news in the Pacific Northwest more broadly. twitter mailto

New York Mets' Pete Alonso, left, stands with Francisco Lindor after flying out with the bases loaded during the fifth inning of a baseball game against the Miami Marlins, Sunday, Sept. 28, 2025, in Miami. (AP Photo/Lynne Sladky, File)2025-12-10T18:28:13Z BALTIMORE (AP) The Baltimore Orioles agreed to a $155 million, five-year deal with slugger Pete Alonso, a person with knowledge of the agreement told The Associated Press on Wednesday.The person spoke to the AP on condition of anonymity because the deal was pending a physical.Its a major move for a Baltimore team that vowed to be aggressive following a last-place finish. Alonso hit .272 with 38 home runs and 126 RBIs this year for the New York Mets, posting an .871 OPS that was his highest since he hit 53 home runs as a rookie in 2019.Alonso, who turned 31 on Sunday, hit 264 homers over seven seasons with the Mets. Hes earned All-Star honors five times, including each of the past four years.Nicknamed the Polar Bear, Alonso became a Citi Field fan favorite as a home-grown member of the Mets. He was NL Rookie of the Year in 2019, when he hit .260 with a major league-high 53 homers a rookie record and 120 RBIs. He had a career-high 131 RBIs in 2022. Alonso batted a career-low .217 in 2023 while hitting 46 homers and driving in 118 runs and hit .240 with 34 homers and 88 RBIs in 2024. After a slow free agent market last winter, Alonso signed a $54 million, two-year contract to stay with the Mets, but he opted out of the final year of the deal.Alonso met with teams at the winter meetings in Orlando, Florida. Pete lives in Tampa, its rather warm there, his agent, Scott Boras, said Tuesday. So the polar vortex of last year has kind of thawed. So the prior market that prior bear market is exhausted.___AP Baseball Writer Ronald Blum contributed to this report.___AP MLB: https://apnews.com/mlb

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09869-0Beneficial effects of fasting combined with endocrine therapy for oestrogen receptor--expressing breast cancers can be recapitulated using exogenous glucocorticoid receptor ligands instead of fasting to reduce harmful effects.

Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-04059-4Archaeological evidence makes a compelling case for Neanderthal-created fires 400,000 years ago in Suffolk, UK plus, how chatbots can sway the opinions of voters.

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09824-zThe tolerogenic activity of type 1 conventional dendritic cells (cDC1s) is determined by EPOR, which is preferentially expressed in cDC1s and induces antigen-specific FOXP3-expressing regulatory T cells.

Nature, Published online: 10 December 2025; doi:10.1038/d41586-025-03734-wTransposable elements can insert into genes, disrupting protein-coding potential. Researchers discover a mode of RNA processing, SOS splicing, that provides a quick fix.

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09829-8An intestinal organoid model recapitulates human microfold (M) cell function and transcriptomic profiling and biochemical assays demonstrate that M cells uptake and present antigens to the immune system via the class II major histocompatibility complex.

Browns quarterback Shedeur Sanders, who was named the team's starter for the remainder of the season on Monday by coach Kevin Stefanski, says he's focused only on this week's opportunity against the Bears.

The Colts will wait to see how this week of practice goes before deciding who will start Sunday at quarterback but Philip Rivers, 44, is under serious consideration.

EA Sports also released its latest Team of the Week for Madden NFL 26.

Andre Snellings digs into the numbers and explains what has to happen for LeBron to get back on track, and what the chances are of that happening this season.

A draft memo from the E.P.A. assumes a safe threshold exists for formaldehyde, upending earlier findings that there is no safe level of exposure to the carcinogen.

The government faces a dilemma over what to do with civil-war-era prisons and detention camps that hold thousands of ISIS fighters and tens of thousands of their family members.

Investigators said that a security camera recorded thieves preparing to burgle the Louvre, but that guards didnt watch the feed in time. The museums director had previously said the camera was facing the wrong way.

Republicans redid their voting maps so they could flip those seats to help keep control of the U.S. House. But achieving that goal is far from guaranteed.

FEMA rejected requests for federal assistance, twice, after devastating floods in western Maryland, part of a larger pattern of making communities pay for their own disaster recovery.

The Golden Globe Awards announced the addition of a new best podcast category, with the inaugural nominees avoiding podcasts that are controversial and politically charged. What do you think?I got into podcasting because Im an idiot, not for accolades.Lou Farmer, Embroidery EnthusiastNow theres a new way for podcasters to be losers.Aaron Barsanti, Hubcap ShinerIf I wanted to hear friends banter for 45 minutes, I would just make friends.Philippa Thorpe, Composting AdvocateThe post Golden Globes Introduces Best Podcast Category appeared first on The Onion.

Travelers wait in a TSA checkpoint at Detroit Metropolitan Wayne County Airport Wednesday, Nov. 26, 2025, in Romulus, Mich. (AP Photo/Ryan Sun)2025-12-10T19:17:59Z WASHINGTON (AP) Foreigners who are allowed to come to the United States without a visa could soon be required to submit information about their social media, email accounts and extensive family history to the Department of Homeland Security before being approved for travel. The notice published Wednesday in the Federal Register said Customs and Border Protection is proposing collecting five years worth of social media information from travelers from select countries who do not have to get visas to come to the U.S. The Trump administration has been stepping up monitoring of international travelers and immigrants.The announcement refers to travelers from more than three dozen countries who take part in the Visa Waiver Program and submit their information to the Electronic System for Travel Authorization, which automatically screens them and then approves them for travel to the U.S. Unlike visa applicants, they generally do not have to go into an embassy or consulate for an interview. DHS administers the program, which currently allows citizens of roughly 40 mostly European and Asian countries to travel to the U.S. for tourism or business for three months without visas. The announcement also said that CBP would start requesting a list of other information, including telephone numbers the person has used over the past five years or email addresses used over the past decade. Also sought would be metadata from electronically submitted photos, as well as extensive information from the applicants family members, including their places of birth and their telephone numbers. The application that people are now required to fill out to take part in ESTA asks for a more limited set of questions such as parents names and current email address.The public has 60 days to comment on the proposed changes before they go into effect, the notice said. CBP officials did not immediately respond to questions about the new rules.The announcement did not say what the administration was looking for in the social media accounts or why it was asking for more information. But the agency said it was complying with an executive order that Republican President Donald Trump signed in January that called for more screening of people coming to the U.S. to prevent the entry of possible national security threats. Travelers from countries that are not part of the Visa Waiver Program system are already required to submit their social media information, a policy that dates back to the first Trump administration. The policy remained during Democratic President Joe Bidens administration.But citizens from visa waiver countries were not obligated to do so.Since January, the Trump administration has stepped up checks of immigrants and travelers, both those trying to enter the U.S. as well as those already in the country. Officials have tightened visa rules by requiring that applicants set all of their social media accounts to public so that they can be more easily scrutinized and checked for what authorities view as potential derogatory information. Refusing to set an account to public can be considered grounds for visa denial, according to guidelines provided by the State Department. U.S. Citizenship and Immigration Services now considers whether an applicant for benefits, such as a green card, endorsed, promoted, supported, or otherwise espoused anti-American, terrorist or antisemitic views.The heightened interest in social media screening has drawn concern from immigration and free speech advocates about what the Trump administration is looking for and whether the measures target people critical of the administration in an infringement of free speech rights. REBECCA SANTANA Santana covers the Department of Homeland Security for The Associated Press. She has extensive experience reporting in such places as Russia, Iraq, Afghanistan and Pakistan. twitter mailto

Michael Gallucci works on the floor at the New York Stock Exchange in New York, Wednesday, Dec. 10, 2025. (AP Photo/Seth Wenig)2025-12-10T03:48:32Z NEW YORK (AP) The U.S. stock market remains largely quiet on Wednesday as Wall Street waits to hear what the Federal Reserve will say in the afternoon about where interest rates may be heading.The S&P 500 was mostly unchanged and remains near its all-time high, which was set in October. The Dow Jones Industrial Average was up 198 points, or 0.4%, as of 12:33 p.m. Eastern time, and the Nasdaq composite was 0.3% lower.Among the markets big movers was GE Vernova, which flew 13.9% higher after the energy company raised its forecast for revenue by 2028, doubled its dividend and increased its program to buy back its own stock. Palantir Technologies added 2.8% after saying the U.S. Navy will use its artificial-intelligence technology as part of a $448 million program.On the losing end of Wall Street was GameStop, which fell 4.8% after reporting weaker revenue for the latest quarter than analysts expected. The video-game retailers profit topped forecasts, though. Cracker Barrel Old Country Store rose 1.1% after swinging between gains and losses. The restaurant chain caught up in a furor around its logo design reported better results for the latest quarter than analysts expected but also cut its forecast for revenue this fiscal year, as well as for an underlying measure of earnings. In the bond market, Treasury yields eased a bit as the countdown ticks toward the Feds announcement at 2 p.m. Eastern time. The widespread expectation is that it will cut its main interest rate for a third time this year in hopes of bolstering the job market. That expectation is so strong that U.S. stock prices have already run to the edge of their records because of it. The more important question for Wall Street will be what Fed officials will say about where they see interest rates potentially heading in 2026. Wall Street has been bracing for Fed officials to imply fewer cuts to rates in 2026 than this year, and potentially fewer than the two that many traders are expecting now, even after they downgraded their forecasts. While lower interest rates can boost the economy and send prices for investments higher, they can also worsen inflation. With inflation remaining stubbornly above the Feds 2% target, Fed officials are notably split about whether high inflation or the slowing job market is the bigger threat to the economy. In the bond market, the yield on the 10-year Treasury edged down to 4.16% from 4.18% late Tuesday. The two-year yield, which more closely tracks expectations for the Fed, dipped to 3.59% from 3.61%. In stock markets abroad, indexes were mixed amid mostly modest movements across Europe and Asia.___AP Business Writers Yuri Kageyama and Matt Ott contributed.

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09822-1A finely balanced ratio of ferredoxin-2 (FDX2) and frataxin (FXN) is essential for the synthesis of ironsulfur clusters, and interventions targeting this ratio could provide a way to treat related diseases, such as Friedreichs ataxia.

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09836-9Data collected from zoos and aquariums worldwide show that hormonal contraception or permanent surgical sterilization in mammals increase life expectancy, with different mechanisms in males and females.

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09855-6Baked sediment, heat-shattered artefacts and introduced pyrite in a 400,000-year-old Palaeolithic occupation site in Suffolk, UK provide evidence of intentional fire-making, marking a pivotal moment in human development.

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09775-5The ALICE Collaboration provides details on the microscopic mechanism that ends up creating antideuteron in high-energy protonproton collisions at the Large Hadron Collider.