Marsupial embryos lack the epigenetic reset seen in placental mammals

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2025-05-19 11:16:27 -

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Nature, Published online: 14 May 2025; doi:10.1038/d41586-025-01477-2Biochemical DNA methylation marks are found across the genome in vertebrate animals, but in the early embryos of placental mammals, such as mice and humans, they are largely erased in a system reset. Surveying DNA methylation in opossum embryos reveals that, in marsupials, such marks are retained.

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