Order in which cancer-driving mutations occur affects the chance of...

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2025-12-03 17:16:24 - Translate -

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Order in which cancer-driving mutations occur affects the chance of tumour development

Nature, Published online: 03 December 2025; doi:10.1038/d41586-025-03748-4What happens to the thousands of intestinal cells that have tumour-initiating DNA mutations? A study in mouse models shows that most are eliminated by strong negative selection, but those that survive create a more-permissive environment for subsequent mutations, opening up routes for cancer to develop.

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