Computational design of metallohydrolases

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2025-12-03 18:17:00 - Translate -

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Nature, Published online: 03 December 2025; doi:10.1038/s41586-025-09746-wA generative artificial intelligence-powered method enables de novo design of highly active enzymes based on information about the geometry of residues in the active site, without requiring protein backbone or sequence information.

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