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Dated gene duplications elucidate the evolutionary assembly of eukaryotes
Nature, Published online: 03 December 2025; doi:10.1038/s41586-025-09808-zAnalysis of eukaryotic gene sequences using a relaxed molecular clock methodology indicate that eukaryotes emerged 3.02.25 billion years ago as a result of mitochondrial endosymbiosis with complex archaea that already possessed an elaborated cytoskeleton, membrane trafficking, endomembrane, phagocytotic machinery and a nucleus.
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