GTP release-selective agonists prolong opioid analgesic efficacy

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2025-12-17 17:16:07 - Перевод -

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Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09880-5Mu opioid receptor agonists with a preference for the non-GTP-bound state of the G protein promote GTP release, thereby potentiating antinociceptive effects of drugs such as morphine and fentanyl without also increasing their respiratory or cardiac effects.

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