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An integrated view of the structure and function of the human 4D nucleome
Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09890-3The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitating the discovery of potential effects of genetic variants, including variants associated with disease, on genome structure and function.
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