Human assembloids recapitulate periportal liver tissue in vitro

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Nature, Published online: 17 December 2025; doi:10.1038/s41586-025-09884-1Hepatocyte organoids derived directly from human tissue enable long-term hepatocyte expansion and can be combined with portal mesenchyme and cholangiocyte organoids to form a donor-specific periportal liver assembloid system.

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