Complete computational design of high-efficiency Kemp elimination...

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2025-06-18 18:27:07 -

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Complete computational design of high-efficiency Kemp elimination enzymes

Nature, Published online: 18 June 2025; doi:10.1038/s41586-025-09136-2We present a computational approach to the design of high-efficiency enzymes with catalytic parameters comparable to natural enzymes, enabling programming of stable, high-efficiency, new-to-nature Kemp elimination enzymes through minimal experimental effort.

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