Mimicking opioid analgesia in cortical pain circuits

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2026-01-07 17:16:17 - Translate -

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Nature, Published online: 07 January 2026; doi:10.1038/s41586-025-09908-wThe anterior cingulate cortex encodes affective pain behaviours modulated by opioids; targeting opioid-sensitive neurons through a new chemogenetic gene therapy replicates the analgesic effects of morphine, providing precise chronic pain relief without affecting sensory detection.

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