How viral RNAs escape a host mechanism that controls translation

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2026-01-07 17:16:21 - Übersetzen -

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Nature, Published online: 07 January 2026; doi:10.1038/d41586-025-04001-8A long-standing question has been how viral RNAs that use genetic codes different from those used in human cells can still drive efficient viral protein production during infection. It emerges that the sequences of 5 untranslated regions in viral RNAs drive codon-usage-independent translation by blocking mRNA circularization, enabling viruses to evade the hosts codon-usage control of translation.

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