RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity

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Nature, Published online: 07 January 2026; doi:10.1038/s41586-025-09852-9Cas12a3 nucleases constitute a distinct clade of type V CRISPRCas bacterial immune systems that preferentially cleave the 3 tails of tRNAs after recognition of target RNA to induce growth arrest and block phage dissemination.

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