Bidirectional CRISPR screens decode a GLIS3-dependent fibrotic cell...

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2026-01-07 22:16:41 - ترجمة -

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Bidirectional CRISPR screens decode a GLIS3-dependent fibrotic cell circuit

Nature, Published online: 07 January 2026; doi:10.1038/s41586-025-09907-xIntegrated single-cell and spatial data analysis, combined with bidirectional CRISPR screens, identify the transcription factor GLIS3 as a key driver of chronic inflammation and fibrosis and a potential marker of disease severity in patients with ulcerative colitis.

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