Rewiring endogenous genes in CAR T cells for tumour-restricted...

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2025-07-02 22:26:13 -

WWW.NATURE.COM

Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery

Nature, Published online: 02 July 2025; doi:10.1038/s41586-025-09212-7A CRISPR knock-in strategy that uses endogenous gene regulatory mechanisms can engineer armoured CAR T cells that secrete proinflammatory cytokines directly within a tumour without causing toxicity, leading to prolonged survival in mice.

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