Polyamine-dependent metabolic shielding regulates alternative splicing

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2026-01-14 19:15:57 - Translate -

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Nature, Published online: 14 January 2026; doi:10.1038/s41586-025-09965-1Polyamines prevent the action of kinases on acidic phosphorylatable motifs in spliceosomal proteins, thus providing a mechanism for metabolite-mediated regulation of alternative splicing in cells.

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