Ligand-specific activation trajectories dictate GPCR signalling in...

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Ligand-specific activation trajectories dictate GPCR signalling in cells

Nature, Published online: 14 January 2026; doi:10.1038/s41586-025-09963-3Different agonists produce equilibria of at least four distinct active states of the G-protein-bound M2 muscarinic acetylcholine receptor, each with a different ability to activate G proteins.

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