A nowhere-to-hide mechanism ensures complete piRNA-directed DNA...

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2026-01-14 23:16:40 - Traduzir -

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A nowhere-to-hide mechanism ensures complete piRNA-directed DNA methylation

Nature, Published online: 14 January 2026; doi:10.1038/s41586-025-09940-wIn mice, a SPOCD1TPR-dependent nowhere-to-hide mechanism is required for complete non-stochastic piRNA-directed LINE1 DNA methylation by preventing transposons from escaping surveillance within heterochromatin.

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