The ubiquitin ligase KLHL6 drives resistance to...

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The ubiquitin ligase KLHL6 drives resistance to CD8<sup>+</sup> T cell dysfunction

Nature, Published online: 14 January 2026; doi:10.1038/s41586-025-09926-8Integrating computational analyses of T cell exhaustion and mitochondrial fitness atlases with in vivo CRISPR screens has identified KLHL6 as a dual-negative regulator of both exhaustion differentiation and mitochondrial dysfunction, highlighting its potential as a target to enhance anti-tumour immunity.

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