The role of metabolism in shaping enzyme structures over 400...

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2025-07-09 22:33:52 -

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The role of metabolism in shaping enzyme structures over 400 million years

Nature, Published online: 09 July 2025; doi:10.1038/s41586-025-09205-6By combining structural biology and evolutionary genomics analyses, the evolution of enzymes over 400 million years is shown to be governed by catalytic function, metabolic network architecture, cost and molecular interactions.

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