Cancer vulnerabilities exposed by finding interactions among DNA...

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2025-04-09 22:16:18 -

WWW.NATURE.COM

Cancer vulnerabilities exposed by finding interactions among DNA repair factors

Nature, Published online: 09 April 2025; doi:10.1038/d41586-025-01049-4A screen of interactions between genes involved in the cells response to DNA damage has revealed several previously unreported synthetic lethalities, in which disrupting a pair of genes, but not either gene alone, causes cell death. The resulting map of genetic interactions could help to identify therapeutic targets for cancer.

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