Brief antibiotic use drives human gut bacteria towards low-cost...

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Brief antibiotic use drives human gut bacteria towards low-cost resistance

Nature, Published online: 23 April 2025; doi:10.1038/s41586-025-08781-xBrief ciprofloxacin exposure in humans drives antibiotic resistance evolution in gut bacteria through selective sweeps, particularly involving DNA gyrase mutations, which persist long after exposure and demonstrate the human guts capacity to promote resistance evolution.

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