PLA2G15 is a BMP hydrolase and its targeting ameliorates lysosomal...

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2025-05-07 17:16:04 - ترجمة -

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PLA2G15 is a BMP hydrolase and its targeting ameliorates lysosomal disease

Nature, Published online: 07 May 2025; doi:10.1038/s41586-025-08942-yLysosomal phospholipase PLA2G15 was identified as a physiological BMP hydrolase whose activity depends on unique esterification and stereochemistry of BMP and offers a potential therapeutic target for NiemannPick disease type C1 and other neurodegenerative conditions.

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