Targeting the SHOC2RAS interaction in RAS-mutant cancers

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2025-05-07 20:16:19 - ترجمة -

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Nature, Published online: 07 May 2025; doi:10.1038/s41586-025-08931-1A study of dependencies associated with cancer-causing mutations has identified a small molecule that binds to SHOC2 and inhibits RAS signalling in cells carrying NRAS Q61 mutations, a common oncogenic driver in melanoma.

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