STAT5 and STAT3 balance shapes dendritic cell function and tumour...

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STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity

Nature, Published online: 14 May 2025; doi:10.1038/s41586-025-09000-3Immune checkpoint blockade activates T cell immunity by reprogramming the STAT3 and STAT5 transcriptional pathways in dendritic cells, and STAT3 degradation is effective for treating tumours of multiple cancer types in mouse models.

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