NSD2 targeting reverses plasticity and drug resistance in prostate...

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2025-11-29 05:17:49 - Translate -

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NSD2 targeting reverses plasticity and drug resistance in prostate cancer

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09727-zInhibition of the histone methyltransferase NSD2 and the androgen receptor in preclinical models can reverse lineage plasticity to suppress tumour growth and promote cell death in multiple subtypes of castration-resistant prostate cancer.

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