Double whammy: drugs that inhibit kinase enzymes also speed up...

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Double whammy: drugs that inhibit kinase enzymes also speed up their disposal

Nature, Published online: 26 November 2025; doi:10.1038/d41586-025-03816-9Cells have evolved elaborate mechanisms to eliminate unwanted proteins and maintain homeostasis. Inhibitors of a diverse family of enzymes called kinases can co-opt and supercharge these protein-degradation mechanisms to prompt kinase degradation.

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