Inhibitory PD-1 axis maintains high-avidity stem-like...

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2025-11-29 09:17:55 - Translate -

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Inhibitory PD-1 axis maintains high-avidity stem-like CD8<sup>+</sup> T cells

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09440-xPD-1 blockade interferes with the selective expansion and maintenance of high-affinity TCR stem-like clones that have a critical role in effective checkpoint blockade therapy.

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