Inhibitors supercharge kinase turnover through native proteolytic...

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2025-11-29 10:17:57 - Translate -

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Inhibitors supercharge kinase turnover through native proteolytic circuits

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09763-9Inhibitor-induced kinase degradation is a common event that positions supercharging of endogenous degradation circuits as an alternative to classical proximity-inducing degraders.

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