Clonal tracing with somatic epimutations reveals dynamics of blood...

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2025-05-21 21:15:38 -

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Clonal tracing with somatic epimutations reveals dynamics of blood ageing

Nature, Published online: 21 May 2025; doi:10.1038/s41586-025-09041-8The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing through cellular differentiation at scale.

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