Effect of phosphorylation barcodes on arrestin binding to a...

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2025-05-22 01:16:05 -

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Effect of phosphorylation barcodes on arrestin binding to a chemokine receptor

Nature, Published online: 21 May 2025; doi:10.1038/s41586-025-09024-9Different phosphorylation patterns created by GRK2 and GRK5 on the C-terminal tail of ACKR3 lead to distinct structural arrangements and dynamics of G-protein-coupled receptorarrestin complexes, potentially explaining diverse cellular outcomes.

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