Cross-regulation of [2Fe2S] cluster synthesis by ferredoxin-2 and...

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Cross-regulation of [2Fe2S] cluster synthesis by ferredoxin-2 and frataxin

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09822-1A finely balanced ratio of ferredoxin-2 (FDX2) and frataxin (FXN) is essential for the synthesis of ironsulfur clusters, and interventions targeting this ratio could provide a way to treat related diseases, such as Friedreichs ataxia.

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