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Reverse electron transport drives metabolic changes in obesity
Nature, Published online: 28 May 2025; doi:10.1038/d41586-025-01621-yMitochondria, best known for converting nutrients into energy, also generate superoxide and hydrogen peroxide redox signalling molecules that become harmful when overproduced. Research reveals that such overproduction is not random, but rather occurs at a specific site in one mitochondrial enzyme, opening the door to targeted therapies for metabolic diseases.
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