A male-essential miRNA is key for avian sex chromosome dosage...

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2025-07-16 16:30:49 -

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A male-essential miRNA is key for avian sex chromosome dosage compensation

Nature, Published online: 16 July 2025; doi:10.1038/s41586-025-09256-9Birds have evolved a unique sex chromosome dosage compensation mechanism involving the male-biased microRNA (miR-2954), which is essential for male survival by regulating the expression of dosage-sensitive Z-linked genes.

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