Ongoing genome doubling shapes evolvability and immunity in ovarian...

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2025-07-16 18:28:11 -

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Ongoing genome doubling shapes evolvability and immunity in ovarian cancer

Nature, Published online: 16 July 2025; doi:10.1038/s41586-025-09240-3A single-cell sequencing study using more than 30,000 tumour genomes from human ovarian cancers shows that whole-genome doubling is an ongoing mutational process that drives tumour evolution and disrupts immunity.

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