Determinants of successful AAV-vectored delivery of HIV-1 bNAbs in...

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2025-07-30 22:25:17 -

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Determinants of successful AAV-vectored delivery of HIV-1 bNAbs in early life

Nature, Published online: 30 July 2025; doi:10.1038/s41586-025-09330-2A single dose of an adeno-associated virus vector encoding an HIV-1 broadly neutralizing antibody given shortly after birth results in persistent antibody expression and protection from infection in rhesus macaque models of human HIV-1 transmission through breastfeeding and sexual intercourse.

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