SuFEx-based antitubercular compound irreversibly inhibits Pks13

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2025-07-31 00:20:54 -

WWW.NATURE.COM

Nature, Published online: 30 July 2025; doi:10.1038/s41586-025-09286-3A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a promising candidate for tuberculosis treatment regimens.

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