NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers

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2025-08-06 22:32:39 -

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Nature, Published online: 06 August 2025; doi:10.1038/s41586-025-09299-yA highly potent and selective small-molecule catalytic inhibitor of the protein lysine methyltransferase NSD2 shows therapeutic efficacy in preclinical models of KRAS-driven pancreatic cancer and lung cancer.

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