Excised DNA circles from V(D)J recombination promote relapsed...

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2025-08-06 22:32:49 -

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Excised DNA circles from V(D)J recombination promote relapsed leukaemia

Nature, Published online: 06 August 2025; doi:10.1038/s41586-025-09372-6Excised signal circles are circular DNA by-products of V(D)J recombination that form a complex with the V(D)J recombinase, and when increased in abundance, result in increased mutagenesis, causing adverse outcomes in cancer.

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