Establishment of chromatin architecture interplays with embryo...

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2025-08-13 16:34:30 -

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Establishment of chromatin architecture interplays with embryo hypertranscription

Nature, Published online: 13 August 2025; doi:10.1038/s41586-025-09400-5A study reveals progressive cohesin loading and a hypertranscription state responsible for the formation of genic cohesin islands at active regulatory genes in mouse embryos, highlighting an interplay between chromatin architecture and transcription as they are established for the first time.

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