Expanding the cytokine receptor alphabet reprograms T cells into...

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2025-08-13 21:34:38 -

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Expanding the cytokine receptor alphabet reprograms T cells into diverse states

Nature, Published online: 13 August 2025; doi:10.1038/s41586-025-09393-1Orthogonal chimeric receptors containing intracellular domains for IL-4R, IL-20R, IL-22R and GCSFR reprogram T cells to promote distinct natural and synthetic cell states with functional and therapeutic implications.

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