NASP modulates histone turnover to drive PARP inhibitor resistance

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2025-08-13 21:34:41 -

WWW.NATURE.COM

Nature, Published online: 13 August 2025; doi:10.1038/s41586-025-09414-zPARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

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