CSN5i-3 is an orthosteric molecular glue inhibitor of COP9 signalosome

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2026-02-11 19:18:04 - Traducir -

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Nature, Published online: 11 February 2026; doi:10.1038/s41586-026-10129-yAn orthosteric CSN inhibitor gains nanomolar potency via a molecular-glue mechanism, stabilizing a CSN5N8inhibitor complex that confers substrate-dependent inhibition despite weak free-enzyme affinity.

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