Immune cells could be protected from exhaustion by flipping genetic switches

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2026-02-11 21:17:16 - Translate -

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Nature, Published online: 11 February 2026; doi:10.1038/d41586-026-00391-5By pinpointing transcription-factor proteins that are selectively engaged when T cells commit to functional or dysfunctional fates, it has been possible to identify regulatory switches that drive this decision. Adjusting these switches restored tumour-killing function while preserving memory capacity.

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