Structural basis for the dynamic regulation of mTORC1 by amino acids

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2025-08-20 17:37:39 -

WWW.NATURE.COM

Nature, Published online: 20 August 2025; doi:10.1038/s41586-025-09428-7Using cryo-electron microscopy, the interactions of Sestrin2 and CASTOR1 with GATOR2 were resolved, revealing how mTORC1 activation is regulated and how nutrient availability triggers signalling for cellular growth.

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