Mechanical confinement governs phenotypic plasticity in melanoma

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2025-08-27 19:34:36 -

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Nature, Published online: 27 August 2025; doi:10.1038/s41586-025-09445-6Mechanical confinement of cancer cells at the tumourmicroenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state in melanoma.

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