One-shot design of functional protein binders with BindCraft

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2025-08-27 20:33:58 -

WWW.NATURE.COM

Nature, Published online: 27 August 2025; doi:10.1038/s41586-025-09429-6BindCraft, an open-source, automated pipeline for de novo protein binder design with experimental success rates of 10100%, leverages AlphaFold2 weights to generate binders with nanomolar affinity without the need for high-throughput screening.

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