Multiple overlapping binding sites determine transcription factor...

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2025-09-03 15:39:38 -

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Multiple overlapping binding sites determine transcription factor occupancy

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09472-3A new method enables comprehensive screening and identification of low-affinity DNA binding sites for transcription factors, and reveals that nucleotides flanking high-affinity binding sites create overlapping low-affinity binding sites that modulate transcription factor binding in vivo.

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