Cocaine-activated ion channels engineered to break the loop of...

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2025-09-03 18:36:13 -

WWW.NATURE.COM

Cocaine-activated ion channels engineered to break the loop of addiction in rats

Nature, Published online: 03 September 2025; doi:10.1038/d41586-025-02609-4Ion channels have been created that are selectively activated by cocaine and that act to either stimulate or inhibit the electrical activity of neuronal cells in the brain. These cocaine-activated ion channels are used to engineer neural circuits in rats to respond to cocaine in a manner that reduces cocaine seeking but not food seeking.

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