Single-cell transcriptomic and genomic changes in the ageing human...

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2025-09-03 19:38:07 -

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Single-cell transcriptomic and genomic changes in the ageing human brain

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09435-8Sequencing analyses of human prefrontal cortex from donors ranging in age from 0.4 to 104 years show that ageing correlates with an accumulation of somatic mutations in short housekeeping genes and a reduction in the expression of these genes.

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